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Preterm neonates are more likely to die from various illnesses including infections and respiratory and neurological complications compared with term neonates. Although preterm survival has increased over the past decade, infants born before 28 weeks of gestation are still at higher risk for adverse outcomes including mortality, morbidity, and neurodevelopmental impairment. Current guidelines recommend clinical surveillance and aggressive care in the nursery for all infants born before 28 weeks of gestation. Among a variety of strategies that are currently being tested to improve outcomes for these vulnerable infants, a reduction in the core temperature to 33-34 degrees C for 72-96 hours seems to be of the most potential to improve short-term and long-term outcomes. The mechanisms responsible for this neuroprotective effect remain unclear, but hypothermia-induced metabolic, cellular, and molecular changes in the developing brain have been hypothesized. 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